ANTIMICROBIAL POTENTIAL OF BARK EXTRACTS OF THE GENUS SORBUS PLANTS
DOI:
https://doi.org/10.32782/naturaljournal.8.2024.1Keywords:
antibiotic-resistant microorganisms, Sorbus plant extract, antimicrobial activityAbstract
The spread of antibiotic resistance of pathogenic microorganisms poses a serious threat to human health and actualizes the search for new antimicrobial agents of natural origin. Plants of the genus Sorbus L. are known in ethnopharmacology, including their antimicrobial ability. The aim of the work was to establish the spectrum of antibacterial and antifungal activity of bark extracts of Sorbus species and natural hybrids. Ethanol extracts of plant bark, obtained by the method of cold maceration, were tested at a concentration of 30 μg/μL. The antimicrobial activity of the extracts was studied by the disc-diffusion method and evaluated by the size of the inhibition zone of the colony’s growth of microorganisms in comparison with reference antibiotics. It was found that the activity of bark extracts of S. aucuparia and S. torminalis was the greatest against Pseudomonas aeruginosa B907 strain (respectively, 63.5% and 53.8% of the ofloxacin level). The greatest inhibition of the growth of Staphylococcus aureus B904 was achieved by the bark extracts of S. hybrida (66.2%) and S. latifolia (60.8%). The growth of the ofloxacin-resistant Proteus mirabilis clinical strain was most inhibited by the bark extracts of S. domestica (inhibition zone diameter 13.5 mm) and S. hybrida (11.9 mm). Against ofloxacin-resistant clinical strain St. epidermidis the most effective were the bark extracts of S. torminalis (inhibition zone 13.8 mm) and S. latifolia (13.5 mm). Clinical fungal strains were resistant to fluconazole but sensitive to bark extracts, most notably Candida albicans to S. domestica (inhibition zone 15.9 mm) and S. hybrida (14.2 mm) extracts, and C. krusei strain to S. aucuparia extract (14.1 mm). Thus, bark extracts of Sorbus plant showed remarkable activity against both Gram-negative and Grampositive collection bacterial cultures, as well as against clinical antibiotic-resistant bacterial and fungal strains. The obtained results confirm the high antimicrobial potential of Sorbus plant bark extracts and the possibility of their use for the creation of effective antimicrobial agents.
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